Sundowns were dealt a blow after 40 minutes when Vilakazi was forced off the field with an injury and Mosimane expects the midfielder to be out for a while.
"I think Vila is going to be out for very long, hopefully Khama (Billiat) comes back. You know because when times on tough you can see some of the guys are crumbling," Mosimane said after the game.
"The load is heavy on Percy, he should not be leading us, the seniors players should be taking over and Percy should be on the side but in tough times that is not the way it is. And games are coming thick and fast, we have a lot of games no one in this country gets games like us. Sometimes we play Tuesday and Wednesday, I have never seen anything like that.
"We play Tuesday and Wednesday and then Friday again Polokwane City. But we are still in for three cups, we just won a cup, we have to go and see how it goes at the end.
"Lets be honest they defended well, they parked the bus, that is all they can do and nothing else. Maybe if I was in the position of the opposition coach, I'd do the same and get a point from Sundowns. But there is still games we still have to go.
"Ya we have to accept, it is football. Look at Barcelona after scoring six goals, what happened last night, they lose."