After thumping Paris Saint-Germain 6-1 earlier in the week, FC Barcelona had their title hopes dented, after they suffered a 2-1 defeat to Deportivo La Coruna on Sunday evening.
The Champions were without the services of Neymar and Rafinha, which saw Andre Gomes and Arda Turan handed starts.
It was the home side who carved out the first chance, as Joselu forced Marc-Andre Ter Stegen into a fine save after 10 minutes.
Luis Enrique's charges struggled to carve out clear cut chances and had to wait until the 37th minute for their first meaningful opening when Lux did well to cut out Sergi Roberto's cross, which was destined for Luis Suarez.
Deportivo broke the deadlock in the 41st minute as Joselu smashed the ball home from close range, after an error from Ter Stegen.
Despite Barca's dominance, the score remained 1-0 to the home side at the halftime break.
However, the Catalan giants leveled matters a minute after the break through Luis Suarez powerful close range effort.
Enrique opted for a double change after 58 minutes as Turan and Gomes made way for Andres Iniesta and Ivan Rakitc.
However, it was Deportivo who restored their lead in the 74th minute Alex Bergantinos steered his header into the bottom corner, 2-1.
Barcelona threw everything forward in the closing stages with the hope of bagging an equaliser, but the Deportivo defence stood firm.
The score remained 2-1 to the home side as the Champions miss the chance to go top, with Real Madrid playing later in the evening.